Tiredness
Fatigue
noun
疲れる is "to be exhausted." This is the noun version, which makes it tiredness or fatigue.
つかれ
The reading comes from 疲れる.
うちの町が大雪に見舞われて、昨日は一日中雪かきしなきゃいけなかったんだよ。もう疲れてクタクタだよ。
Heavy snow hit my town and I had to shovel it all day yesterday. I’m already worn out.