Tiredness
Fatigue
noun
疲れる is "to be exhausted." This is the noun version, which makes it tiredness or fatigue.
The reading comes from 疲れる.
疲れをいやす
to relieve fatigue
疲れを感じる
to feel tired
疲れをとる
to get rid of fatigue
疲れを知らない
to be tireless
疲れが出る
fatigue sets in, fatigue shows
疲れがとれない
unable to shake off fatigue
疲れがたまる
fatigue accumulates
疲れがとれる
fatigue is relieved
お疲れ
good work (set phrase), fatigue (honorific)
ネコは疲れをいやしてくれるよ。
Cats will soothe you when you're tired.
年のせいか、疲れが中々とれないんだよね。
Maybe it's because I'm old, but I can't shake off my fatigue easily.
うちの子は、疲れ知らずで、一日中ずーっと走り回ってられるんです。
Our little boy is tireless and can run around all day long.