Fatigue
Noun
つかれ
うちの町が大雪に見舞われて、昨日は一日中雪かきしなきゃいけなかったんだよ。もう疲れてクタクタだよ。
Heavy snow hit my town and I had to shovel it all day yesterday. I’m already worn out.
疲れる is "to be exhausted." This is the noun version, which makes it tiredness or fatigue.
The reading comes from 疲れる.