You
pronoun, の adjective
A valuable formal name title. It's like saying something like "the valuable great you"... or something. Anyways, this means you, but it isn't as nice as it sounds. Probably a lot of irony and sarcasm going into this word, because if you use きさま to say "you" to someone, you're probably not pleased with that person, or you're just trying to be rude.
The readings are the reading you learned with 貴 plus the vocab reading for 様.
貴様がうるさかったせいで、昨日全然寝れなかったじゃねぇか。
I couldn’t sleep well because YOU were very noisy.