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Suffering and labor. Sounds like the kind of thing these soft hands wouldn't want to deal with. These are hardships and troubles. Hopefully you don't have too much of this with kanji anymore!
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
苦労をする
to have a hard time
苦労を知る
to know hardship
苦労をかける
to cause someone trouble, to cause someone anxiety
ワニカニに出会うまでは、おれの人生は苦労ばかりだった。
My life was full of hardships until I came across WaniKani.
このコウイチのサイン、苦労してやっと手に入れたんだよ。
I went through hardship to finally get Koichi's autograph.
うちのお風呂って、シャワーの位置が固定されちゃってるから、バスタブを洗って流すときにかなり苦労するんだよね。
In my bathtub, the position of the shower is fixed, so it is quite difficult to wash and rinse.
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