There is a saying, "Your efforts will not betray you," but it's a lie.
In spite of his grueling efforts, he didn't win the lottery.
Even if you make a great effort, it doesn’t mean you get results.
You toil and use your strength. Ugh! How difficult. You really put in a great effort.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.