This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
There is a saying, "Your efforts will not betray you," but it's a lie.
In spite of his grueling efforts, he didn't win the lottery.
Even if you work hard, if you don't have results, there isn't a point to it.