I often fall asleep on the train and have to be woken up by the driver at the last stop.
What's the name of the last stop on the Amtrak leaving from Chicago?
You have to do me a favor. No matter what I say, no matter what I do, please do not let me get out of the train until it gets to the last stop. Okay?
The end point is where everything ends... but for this example, think of a map with a route on it. The last spot on the route is the "last point." It is the last stop.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.