I missed the last part of my favorite drama and cried.
The train we just took was the last one of the day, so we can't go back anymore.
This is our final offer. Now the ball is in your court.
The most end thing is the last thing.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.