This airplane is nonstop to Tokyo.
Today after the meeting with Japan, I'll go directly to the appointment with Tofugu.
I’m sorry, I can't talk right now. I’m on a nonstop trip to the bathroom.
If you think about direct going (aka transportation) how would you make it better? You'd make it so everything was nonstop and direct. Just imagine how much nicer it would be if every airplane you took was direct and you never had to stop. So nice!
This is a jukugo word and uses the on'yomi readings of the kanji. The ちょく of 直 is shortened with a small っ, though, so make sure to take note of that.