Exhaustion
Impoverishment
If you're exhausted by all the evil things in your life you might die of exhaustion!
ひへい
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
人口が増えない限り、地方経済の疲弊が回復することはないでしょう。
It seems that the local economy will not recover from impoverishment unless the population increases.