If you're tired by all the evil things in your life you might die of exhaustion!

While 疲労 and 疲れ mostly refer to physical or mental fatigue, 疲弊 describes being depleted and exhausted due to prolonged stress, overwork, or long-term difficulties. As a result, it can also be used to describe economic or financial exhaustion.

This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.