Singer
noun
Remember how 手 can sometimes refer to a person? In this case, we have a song person (or perhaps a "person who handles songs"). What is a song person also known as? A singer.
かしゅ
The readings are on'yomi readings. You've learned them both already (you learned 手's on'yomi reading with word 投手), so you should be able to read this like a singer sings with a bunch of cashews かしゅ in their mouth. FAST AND LOUD!
歌手になったのは、母のえいきょうが大きいです。
My mother had a large influence in my becoming a singer.
あの歌手、かなり日やけしたね。
That singer got quite a tan, didn't she?
子どもの頃は、歌手だったのよ。なんちゃってね。今でも歌手なんですけど。
I used to be a singer when I was kid. Well, who am I kidding, I’m still a singer now.