I already have nothing to lose.
The information that Tofugu gambled away its entire assets is not reliable.
The worst day of my life was when I lost my AKB48 Barbie doll.
The kanji portion means fault, so you would think the verb version is "to fault." It's a little different, though. Think of it this way, if you "fault" something, you're messing up. What's a great way to mess up? By losing something. That's why this word means to lose.
Pretend like you are supposed to hold on to someone's wedding ring. You make the biggest fault of all. You lose it. Ouch.
Since this word consists of a kanji with hiragana attached, you can bet that it will use the kun'yomi reading. You didn't learn that reading with this kanji, so here's a mnemonic to help you:
How did you lose this wedding ring? An 牛 Nun (うし + な) ate it. The only way to get it back is to cut open this cow nun and get it back.