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You know how 失敗 is a mistake? Well, a large mistake is going to be a total failure or a huge mistake. So terrible!
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well. It will help to know 失敗 on its own as well.
そのプロジェクトは大失敗に終わりました。
The project ended in a big failure.
それはとんだ大失敗でしたね。
That was a terrible mistake.
私の大失敗のせいで、今月はワニカニの売り上げが五十パーセントも減ってしまいました。
Because of my fiasco, WaniKani sales decreased by fifty percent this month.
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