I made the big mistake of farting during the silence.
Our idea of having Mami watch Koichi's bacon was a total failure. She ate every single piece.
In the meeting yesterday, Shark really made a huge mistake. I think he might lose his position.
You know how 失敗 is a mistake? Well, a large mistake is going to be a total failure or a huge mistake. So terrible!
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well. It will help to know 失敗 on its own as well.