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The kanji and the word are exactly the same. That means they share meanings as well. This is more the "strange" meaning though, not the "change" one. As in, you 変な猫！
The reading is the one you learned with the kanji. How strange! Or not.
それってちょっと変じゃない？
Isn't that a bit unusual?
なんかあそこに変な人がいる。
There's someone strange over there.
変だなぁ。僕のメールボックスには、君が送ったと言っているメールがどこにも見当たらないよ。
That’s strange. I can’t find the email you say you sent me anywhere in my mailbox.
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