If he’s angry, it can’t be helped.
There's no use in just crying.
You’re really hopeless!
The kanji part of this word is like saying "the doing way" ... aka the way you do something. So, when you don't have a way to do something, there's nothing you can do. Thus is born the popular Japanese phrase: 仕方がない, which means can't be helped, it's no use, or there's no other way. This is a very good expression to know if you're in Japan.
The readings for the kanji portion are in line with the readings you learned with the individual kanji, so as long as you know those you should be able to read this word as well.