To Appoint
To Assign, To Designate, To Specify
する verb, transitive verb
When you determine and use your finger to point at someone or something, you're going to appoint them. Just imagine yourself determining who's the best for the job then pointing with your finger. That is who you will appoint. The する on the end makes it a verb, so 指定 would be "appointment" or "designation" or something along those lines. Cool how する works.
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
ミーティングの場所は、お客さまが指定しました。
The meeting place was designated by the client.
ウェブでチケットを予やくしても、自分でせきを指定することはできますか。
If I book a ticket on the web, can I still choose my seat?
向こうに指定された喫煙エリアがあるから、私にじゃなくてそこに行って喫煙者がどれだけ臭いかについて文句を言った方がいいんじゃない。
There is a designated smoking area over there, so you should go there and complain how stinky smokers are instead of just telling me.