What do you hit to make a sick beat? A cool little hand drum.
Since this word is made up of a single kanji, it probably uses the kun'yomi reading. You did not learn this reading, so here's a mnemonic to help you:
You like to use your hand drum when two dudes meet (つづみ). You drum and tap it and it as they high five and it makes them super uncomfortable which makes you super happy. That's why you love your hand drum so much.
The way that woman hit her hand drum was superb.
She put away the hand drum carefully in the bag.
I've never seen such a cute tsuzumi. Did you make it, by any chance?