We also had a ton of debt when we opened our business.
As of this year, this eye doctor has been in practice for 35 years.
I blew off school yesterday to help Koichi prepare for the opening of his business.
This is one of those words that has kanji that basically tell you the meaning. You open a business... aka opening a business.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.