Hindrance
Intrusion
noun, する verb, な adjective
A wicked devil! Ugh, I hate those things. They're always a hindrance and intrusion. Just imagine a wicked devil hanging out in your house, eating your food, and sleeping on your bed. What a hindrance.
じゃま
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
私の邪魔をするな。一人で出来るよ！
Don’t stand in my way. I can do it by myself!