Each reading has a slightly different meaning. Here's some mnemonics to help you remember them:
You need to avoid people who drink sake (さけ) all the time. Why? Because when they get drunk you'll have to dodge the yo-yos (よ) they spin at you. Sake makes you want to toss the ol' yo-yo around. Avoid them or you'll have to get good at dodging!
I’m going to show my mother the famous sights of Tokyo by car tomorrow, so do you know any good ways to avoid the traffic?