I was in Okinawa over the weekend.
We got 10 centimeters of snow last weekend.
We just won the lottery, so do you want to go to Rome this weekend for pizza?
The end of the week is the weekend... that is, unless you work on the weekend, but we can't cater to everyone here.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.