Chain
Chaining, Connection
noun, する verb
If you take along a chain with you it's still a chain, it's just moving somewhere new.
れんさ
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
まずはこの負の連鎖を断ち切る必要があります。
First, you must sever ties with this negative chain.