Noun
にし
びょういんの西のたてものがわたしのアパートです。
The building on the west side of the hospital is my apartment.
ダリンは、西にむかっています。
Darin is heading west.
その頃、西ポートランドでは、鰐蟹がその道を渡っていた。
Meanwhile in West Portland, the Crabigator was crossing the road.
The kanji and the word are exactly the same. That means they share meanings as well.
Since this word is made up of a single kanji, it should use the kun'yomi reading. When learning the kanji, you didn't learn that reading, so here's a mnemonic to help you with this word:
You go off to the west. It's the Wild West, even. There aren't many people out here, making it easy to find a niche (にし) for your snake oil business.