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The kanji and the word are exactly the same, so this means nephew.
In casual conversation, you may more often hear 甥っ子, which is a friendlier and more affectionate-sounding way to talk about your nephew.
The reading is the same as the one you learned with the kanji.
甥は今年、中学生になった。
My nephew became a middle school student this year.
甥っ子と公園でキャッチボールをした。
I played catch with my nephew at the park.
今のって、甥っ子ちゃん?大きくなったね!
Was that your nephew? Wow, he's gotten so big!
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