Being Autonomous, Independent
noun, の adjective, verbal noun
Alone I stand. I have independence!
独立 often implies both being autonomous and independent. While it can also refer to self-reliance, it's more commonly associated with political independence or independence from organizations.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
If you say not many people who left the company and went independent succeeded, show me the data, their plans, and how they failed.