The kanji and the word are exactly the same. That means they share meanings as well.
Since this word is made up of a single kanji, it should use the kun'yomi reading. When learning the kanji, you didn't learn that reading, so here's a mnemonic to help you with this word: You're standing around a smoke machine. It's billowing up smoke. Strangely, your buddy Bill Murray is here too. For some reason, he loves the smoke, and he puts his head in it, breathing it in deeply until he goes into a coughing fit. You decide it's time to stop him. "Kay, Murray (けむり), it's time to stop that," you say.
The city of Portland was covered with fire and smoke.
Hey! Smoke is coming out of the grill!!
Viet was surprised to see smoke rising from the other side of Koichi’s computer because smoking is banned in the office.