Impossible
Unreasonable, Overdoing
noun, verbal noun, な adjective
If you can do nothing within reason, then what you're trying to do is unreasonable and probably downright impossible. If you still try, you're probably just overdoing it.
This is a jukugo word, which usually means on'yomi readings from the kanji. As long as you know the readings for these kanji, you should be able to read this word just fine.
コウイチはニンニクは便ぴを治す薬だって言ってたけど、ニンニクで便ぴを治すのは無理でしょ。
Koichi said that garlic is a cure for constipation, but I'd say curing constipation with garlic is impossible.
コウイチが無理なん題をふっかけても、トーフグチームは無理してなんとかやってのける。
Even though Koichi makes unreasonable demands, the Tofugu team manages to meet them by overworking themselves.
自分の肘を舐めるのは無理です。
It’s impossible to lick your own elbow.