Koichi usually works without taking holidays.
Kana and Mami are making WaniKani example sentences without any breaks.
Tofugu’s website is always open, twenty-four hours a day, every day of the year.
If rest is nothing then there are no holidays. If there are no holidays, then that means a place is always open.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.