How can you drink such terrible, garbage alcohol?
Maybe it was the worst kiss ever.
Wow, I can’t believe you got the lowest score on the test. What a bummer!
The most low is the lowest. It's also what you call something when you think it's the worst or just plain terrible. Try yelling this out when you're disgusted about someone or something.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.