First things first. Let’s start by cleaning your room.
Sweep and exclude all that dirt from the floor, please. When you do this a lot, it becomes cleaning.
This is a jukugo word, which usually means on'yomi readings from the kanji. For this one though, you have to remember to read the 除 part as じ. Just keep in mind that cleaning (cleanliness) is next to godliness and so is Jesus (じ). So, Jesus is like cleaning. Easy.