This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well. Take note that the ぱい in 配 got rendaku'd from はい, as well.
I’m worried because it’s unusual for him to be so down.
I got worried about whether the ship was heading east or west.
Don’t worry, everything is going to be fine. You can believe what I say.