I’m worried because it’s unusual for him to be so down.
I got worried about whether the ship was heading east or west.
Don’t worry, everything is going to be fine. You can believe what I say.
When you distribute your heart around you, it's like your heart is everywhere at once, but not in your body. You feel frantic, you don't know what to do because your heart is out there. This represents the feeling you have when you have a worry or concern. 心配しないでね！
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well. Take note that the ぱい in 配 got rendaku'd from はい, as well.