To Devote Oneself
To Sink In, To Penetrate
する verb
If you do penetrate, sure, you can to penetrate. But, if you penetrate something you really get into it, like, you are going to devote oneself.
The reading comes from the one you learned with the kanji. Look out for the shortening on this one.
ギャンブルに徹する覚悟を決めました。
I am determined to devote myself to gambling.