To Exhaust Something
To Run Out, To Do To Exhaustion, To Devote Oneself
intransitive verb, transitive verb, godan verb
尽きる is "to be exhausted". 尽くす is when you're doing the exhausting of something, which makes it to exhaust something or to run out. It can also mean to devote oneself to a certain cause.
The reading comes from 尽きる.
「これ、明日までにできるかな？」「わかりました。最善を尽くします。」
"Can you do this by tomorrow?" "I see, I’ll give it my best."
食料の備蓄を食べ尽くしてしまった。
We ate up all the emergency food stocks.
ビエトはヤクザ界のことを知り尽くしている。
Viet knows everything about the yakuza world.