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Something that obstructs and also does damage is an obstruction. No obstruction is ever good and if left too long it really will cause damage and interference as well.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.
これ以上妨害するのを止めないと、営業妨害で訴えるぞ!
If you don't stop interfering, I'll sue you for obstruction of business operations!
ここまで来れば、敵の妨害の危険はほぼ無いだろう。
Now that we've come this far, the risk of being intercepted by the enemy should be practically zero.
私はいつか映画のように公務執行妨害で逮捕されてみたい。
Someday I want to be arrested for interfering with police officers' duties, like in the movies.
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