"I don’t want to go to Hogwarts School of Witchcraft and Wizardry anymore. I want to be an actress." "Oh, don’t be ridiculous, Hermione."
Remember how 男優 was "actor"? Well, I bet you can extrapolate what this one means because it now has woman in it. This is an actress.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.