Wife
noun
The interior person (the honorific さん shows it's a person) is the person who stands in the interior of the house and doesn't leave, making that person your wife. Ouch. Sexist kanji strikes again.
The reading comes from what you learned in the kanji.
「おまえの奥さんって、どんな人？」「彼女は何でもバリバリやるタイプだよ。」
"What kind of person is your wife?" "She’s the type that does everything energetically."