Remember how you learned that 大腸 means "large intestines?" Well when you get bacteria in there you end up with E. Coli. Go to a doctor right away! You're gonna be stuck in the bathroom for a while. Sorry...
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
There’s a card app game that personifies E. Coli as a beautiful woman.