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A big resist is something he generally and usually does... at least in most cases. He's usually a big resistor, that one.
This is a jukugo word that uses the on'yomi readings of the kanji. You should be able to read this on your own.
大抵の外国人は納豆が苦手かと思いますが、私もその一人です。
I think most foreigners usually don't like natto and I'm one of them.
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