In my school days, I took a backpacking trip through South America.
This hotel's tap water is the best water I’ve ever had in South America.
I’m sorry. I thought South America was a part of the United States of America.
Remember how 米国 can also mean America? That goes for North and South America, actually, not just the United States. So, south America is South America.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.