I’m taking a one year leave of absence from university.
When Viet was a college student, he took a year of leave from school and went on a journey of self discovery.
"Do you know why Kelly has been absent from school for the past three weeks?" "Yes, apparently she has a really serious case of pink eye."
When you rest from school you are absent from school. This is only for very long absences though, not a day or a week, but months or years. Think about it like taking an extended leave of absence from school.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.