Proper noun and な adjective
ちゅうとう
けさ、テレビで中東のニュースを見ました。
I watched the news on the Middle East on TV this morning.
きんきゅうじたいで中東に行かなくてはいけなかったんだから、けっこんしきに来れなかったのは仕方がないよ。
You can't help it that you couldn't make it to the wedding because you had to go to the Middle East for an emergency.
中東で一番楽しまれているゲームは何ですか？
What is the most played game in the Middle East?
The middle of the east is more simply known as the middle east.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.