I watched the news on the Middle East on TV this morning.
You can't help it that you couldn't make it to the wedding because you had to go to the Middle East for an emergency.
What is the most played game in the Middle East?
The middle of the east is more simply known as the middle east.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.