You look as if you're in the depths of misfortune. Are you okay?
There was a death in my family. Can I take tomorrow and the day after off?
They say misery loves company, which explains why I’m dating you.
When you do not have happiness, you have unhappiness, misfortune and misery. This can also mean death, usually of a family member.
This is a jukugo word, which usually means on'yomi readings from the kanji. If you know the readings of your kanji you'll know how to read this as well.