Madam, Miss, Mx
The kanji means family name because it goes after a family name in very formal situations. So, it's really closely tied to that. Because only men got the respect back in the day, we're calling this vocab word mister. You can call me Mr. Koichi if you'd like, too.
The reading for this word is the same as the kanji.
Mister Bill Gates was born in Seattle.
Mr. Tanaka never came.
This is a letter from Mr. Trump.