As we all know, Mr. Abe’s statements never change.
Mr. Koichi and Mr. Viet have good chemistry.
Yo, Mr. White, why don’t you just sit down?
The kanji means family name because it goes after a family name in very formal situations. So, it's really closely tied to that. Because only men got the respect back in the day, we're calling this vocab word mister. You can call me Mr. Koichi if you'd like, too.
The reading for this word is the same as the kanji.